Using a 3.19 fb-1 data sample collected at the s=4.178 GeV with the BESIII detector, we search for the rare decay Ds+→ppe+νe. No significant signal is observed, and an upper limit of B(Ds+→ppe+νe)<2.0×10-4 is set at the 90% confidence level. This measurement is useful input in understanding the baryonic transition of Ds+ mesons. © 2019 authors. Published by the American Physical Society.