The traffic on the Indian highway; is heterogeneous in nature. VehicleS with widely varying static and dynamic characteristic; occupy the common carriageway space. The speed differentials between the vehicle; of the same clasS and different claSSe; significantly contribute to road crashes on the highway;. The operating speed; of the different vehicle types vary widely. The design speed iN different from the operating ;peed; observed on the highway;. Design of the road geometric; for ;afetv considering vehicles with widely varying static and dynamic characteristics i; a challenging taLk to the designers. The present research work attempts to develop safety prediction model; for inter-city highway; catering to heterogeneou; traffic considering the operating speeds of vehicles and relating it to crashes duly considering the roadway geometric elements. A typical four lane highway is considered m the research study. The data on roadway geometric; at different sections along the highway, the traffic details and other elements contributing to the road crashes are collected along with the road accident data for a penod of four years. Statistical analysis was carried out to develop safety predicnon models. The models may be used in assesment of safety performance of four lane rural highways under heterogeneous traffic condition; and m the calibration of Interactive Highway Safety DeSign Models for mixed traffic condition;.