Motivated by the numerous applications of spherical shell models in micro and nano scales (such as microbubbles, bacterial cells, and viral capsids), we have considered the axisymmetric free vibrations of a spherically isotropic fluid-filled thick microspherical shell suspended in another unbounded fluid. A partial-slip condition is considered at the solid-fluid interface(s). Three-dimensional linear elasticity equations for the spherically isotropic shell dynamics and linearized Navier-Stokes equations for the two compressible viscous fluids are used in the analysis. The eigenvalue problem is discretized and solved to find the resonances and quality factors. A perfectly matched layer technique is used to separate the solid driven spectrum from the boundary reflecting spectrum. An example of air filled polymer shell suspended in water is presented. The added mass effect and partial-slip condition from water (air) on the frequencies and quality factors are found to be significant (negligible). Spherical isotropy is found to have major influence on the low frequency and large meridional wave number region of the resonance spectrum. High quality eigenmodes are observed due to very small viscous penetration depth compared to the shell size. In the thin-shell limit, the eigenvalue problem can have only two modes of vibration for any meridional wave number greater than or equal to two. This explains the reason for the second resonance frequency found for the quadrupole shape oscillations of various bacterium cells in the earlier work. The partial-slip condition is found to have very small influence on the first few modes of vibration. Surface tension is found to have significant influence only on the lowest frequency trend of the eigenspectrum. Perfectly matched layer technique used in the present analysis is found to be very effective in handling the boundary truncated problems. © 2015 AIP Publishing LLC.