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Quantification of doxorubicin in biofluids using white light excitation fluorescence
John Prakash,
Published in Wiley-VCH Verlag
2014
PMID: 23585121
Volume: 7
   
Issue: 8
Pages: 607 - 616
Abstract
A fiber optic spectrometer setup was designed for white light excitation fluorescence 'WLEF' based measurements. Using this setup, two different analytical methods, a self referencing ratio-metric and a difference WLEF methods, were developed for the quantification of doxorubicin (DXR) in biofluids. It was seen that Acetonitrile (ACN) acts as an efficient and transparent extracting medium for DXR. The figures of merit and the percent recoveries of DXR in blood serum, even in presence of external fluorophores and in urine samples are comparable with existing analytical methods. The compact spectrometer is expected to be useful for easy quantification of fluorescent pharmaceuticals in biofluids. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
About the journal
JournalData powered by TypesetJournal of Biophotonics
PublisherData powered by TypesetWiley-VCH Verlag
ISSN1864063X
Open AccessNo
Concepts (24)
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    Blood
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    Spectrometers
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    Anticancer drug
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    BLOOD SERUM
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    Doxorubicin
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    FIBER-OPTIC SPECTROMETERS
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    Riboflavin
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    Urine
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    White light
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    Fluorescence
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    Adult
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    Blood analysis
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    Devices
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    Fiber optics
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    Human
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    Light
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    Male
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    Procedures
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    Spectrofluorometry
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    Urinalysis
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    BLOOD CHEMICAL ANALYSIS
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    FIBER OPTIC TECHNOLOGY
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    Humans
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    Spectrometry, fluorescence