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PROXiMATE: a database of mutant protein-protein complex thermodynamics and kinetics
Published in
2017
PMID: 28498885
Volume: 33
   
Issue: 17
Pages: 2787 - 2788
Abstract
Summary: We have developed PROXiMATE, a database of thermodynamic data for more than 6000 missense mutations in 174 heterodimeric protein-protein complexes, supplemented with interaction network data from STRING database, solvent accessibility, sequence, structural and functional information, experimental conditions and literature information. Additional features include complex structure visualization, search and display options, download options and a provision for users to upload their data.Availability and implementation: The database is freely available at http://www.iitm.ac.in/bioinfo/PROXiMATE/ . The website is implemented in Python, and supports recent versions of major browsers such as IE10, Firefox, Chrome and Opera.Contact: gromiha@iitm.ac.in.Supplementary information: Supplementary data are available at Bioinformatics online. © The Author (2017). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com
About the journal
JournalBioinformatics (Oxford, England)
ISSN13674811
Open AccessNo
Concepts (14)
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    Mutant protein
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    Chemistry
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    Factual database
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    Genetics
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    Kinetics
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    Metabolism
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    Missense mutation
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    Protein domain
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    Protein multimerization
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    Thermodynamics
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    Databases, factual
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    Mutant proteins
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    Mutation, missense
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    Protein interaction domains and motifs