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Probiotics, prebiotics and colorectal cancer prevention
Maya Raman,
Published in Bailliere Tindall Ltd
2016
PMID: 27048903
Volume: 30
   
Issue: 1
Pages: 119 - 131
Abstract
Colorectal cancer (CRC), the third major cause of mortality among various cancer types in United States, has been increasing in developing countries due to varying diet and dietary habits and occupational hazards. Recent evidences showed that composition of gut microbiota could be associated with the development of CRC and other gut dysbiosis. Modulation of gut microbiota by probiotics and prebiotics, either alone or in combination could positively influence the cross-talk between immune system and microbiota, would be beneficial in preventing inflammation and CRC. In this review, role of probiotics and prebiotics in the prevention of CRC has been discussed. Various epidemiological and experimental studies, specifically gut microbiome research has effectively improved the understanding about the role of probiotics and microbial treatment as anticarcinogenic agents. A few human studies support the beneficial effect of probiotics and prebiotics; hence, comprehensive understanding is urgent to realize the clinical applications of probiotics and prebiotics in CRC prevention. © 2016 Elsevier Ltd. All rights reserved.
About the journal
JournalBest Practice and Research: Clinical Gastroenterology
PublisherBailliere Tindall Ltd
ISSN15216918
Open AccessNo
Concepts (35)
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    ANTIMUTAGENIC AGENT
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    Antineoplastic agent
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    Carcinogen
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    PREBIOTIC AGENT
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    PROBIOTIC AGENT
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    Protein tyrosine kinase
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    SYNBIOTIC AGENT
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    PREBIOTIC AGENT
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    PROBIOTIC AGENT
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    Antineoplastic activity
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    Apoptosis
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    Article
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    CANCER PREVENTION
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    Cell differentiation
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    COLON CARCINOGENESIS
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    Colorectal cancer
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    DYSBIOSIS
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    Human
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    Immunomodulation
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    In vitro study
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    Intestine flora
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    Nonhuman
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    Signal transduction
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    STOMACH PH
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    COLORECTAL NEOPLASMS
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    Diet
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    Immune system
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    Microbiology
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    Physiology
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    ANTICARCINOGENIC AGENTS
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    COLORECTAL NEOPLASMS
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    Gastrointestinal microbiome
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    Humans
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    Prebiotics
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    PROBIOTICS