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Book Chapter
Potential anti-inflammatory and antiproliferative agents and 1H-isochromen-1-ones and their thio analogues and their QSAR studiesPublished in CRC Press
2016
Pages: 385 - 398
A series of 1H-isochromen-1-ones and their thio analogues (1H-isochromen-1-thione) has been considered for evaluation of their cytotoxic effect on the H460 cancer cells by a propidium iodide assay. A quantitative structure-activity relationship has been developed between the cytotoxicity against H460 (at 0.1 μM) and the structural features of the compounds. Statistical measures such as r2 (0.86), q2 (0.58), pred-r2 (0.94), and F-ratio (15.22) were found to be in an acceptable range. © 2016 by Apple Academic Press, Inc.
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About the journal
| Journal | Chemometrics Applications and Research: QSAR in Medicinal Chemistry |
|---|---|
| Publisher | CRC Press |
| Open Access | No |
Authors (1)
Mukesh Doble- Design, synthesis and identification of novel coumaperine derivatives for inhibition of human 5-LOX: Antioxidant, pseudoperoxidase and docking studies
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