Header menu link for other important links
X
Optimization of a biochemical fed-batch reactor using sequential quadratic programming
Published in ACS, Washington
1999
Volume: 38
   
Issue: 5
Pages: 1998 - 2004
Abstract
In this paper, we discuss the use of sequential quadratic programming to obtain the optimum feed rate strategy for the fed-batch operation of two biochemical systems: (I) lysine and (II) alcohol fermentation. We consider the constrained optimization problem where the reactor operation is such that the final volume is fixed. Both fixed and free time of operations are considered. In this approach, the entire duration of the reactor operation is divided into equal subintervals. The feed rate is approximated as discretized charges which are added to the reactor at the beginning of each subinterval. The effect of the number of stages on the optimum performance for both systems is investigated. The results are compared with those obtained using Pontryagin's maximum principle in the literature. The advantages and the applications of using this approach are discussed.In this paper, we discuss the use of sequential quadratic programming to obtain the optimum feed rate strategy for the fed-batch operation of two biochemical systems: (I) lysine and (II) alcohol fermentation. We consider the constrained optimization problem where the reactor operation is such that the final volume is fixed. Both fixed and free time of operations are considered. In this approach, the entire duration of the reactor operation is divided into equal subintervals. The feed rate is approximated as discretized charges which are added to the reactor at the beginning of each subinterval. The effect of the number of stages on the optimum performance for both systems is investigated. The results are compared with those obtained using Pontryagin's maximum principle in the literature. The advantages and the applications of using this approach are discussed.
About the journal
JournalIndustrial and Engineering Chemistry Research
PublisherACS, Washington
ISSN08885885
Open AccessNo
Concepts (18)
  •  related image
    Alcohols
  •  related image
    Constraint theory
  •  related image
    Fermentation
  •  related image
    Quadratic programming
  •  related image
    Lysine
  •  related image
    Pontryagin's maximum principle
  •  related image
    SEQUENTIAL QUADRATIC PROGRAMMING
  •  related image
    Bioreactors
  •  related image
    Alcohol
  •  related image
    Batch process
  •  related image
    Computer program
  •  related image
    Optimization
  •  related image
    Article
  •  related image
    Biomass
  •  related image
    Bioreactor
  •  related image
    Mathematical analysis
  •  related image
    SEQUENTIAL ANALYSIS
  •  related image
    Time