This paper presents an experimental and analytical investigation on the response of reinforced cement concrete bare and non-integral brick masonry infilled frames under lateral reversed cyclic loads. Quarter scale three-storey models were tested under varying storey shears. A detailed analysis has been carried out by employing nonlinear finite element method to account for the following material nonlinearities - (a) cracking in reinforced concrete frame and brick infill, (b) yielding of concrete, infill and reinforcement, (c) slip, separation and recontact at the frame-infill interface, and (d) opening and closing of tracks in concrete and infill. The analysis has been carried out for both monotonic and cyclic loads. The infill-frame interaction is found to enhance the base shear capacity, improve the hysteretic behaviour and alter the failure mode of the bare frame.