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Nanomechanical characterization and molecular mechanism study of nanoparticle reinforced and cross-linked chitosan biopolymer
Published in Elsevier Ltd
2016
PMID: 26540519
Volume: 55
   
Pages: 42 - 52
Abstract
Chitosan (CS) is a biomaterial that offers many sophisticated and innovative applications in the biomedical field owing to its excellent characteristics of biodegradability, biocompatibility and non-toxicity. However, very low mechanical properties of chitosan polymer impose restriction on its further development. Cross-linking and nanoparticle reinforcement are the two possible methods to improve the mechanical properties of chitosan films. In this research, these two methods are adopted individually by using tripolyphosphate as cross-linker and nano-hydroxyapatite as particle reinforcement. The nanomechanical characterizations under static loading conditions are performed on these modified chitosan films. It is observed that nanoparticle reinforcement provided necessary mechanical properties such as ductility and modulus. The mechanisms involved in improvement of mechanical properties due to particle reinforcement are studied by molecular dynamics (MD). Further, improvement in mechanical properties due to combination of particle reinforcement and cross-linking agent with chitosan is investigated. The stress relaxation behavior for all these types of films is characterized under dynamic loading conditions using dynamic mechanical analysis (nanoDMA) experiment. A viscoelastic solid like response is observed for all types of film with modulus relaxing by 3-6% of its initial value. A suitable generalized Maxwell model is fitted with the obtained viscoelastic response of these films. The response to nano-scratch behavior is also studied for particle reinforced composite films. © 2015 Elsevier Ltd.
About the journal
JournalData powered by TypesetJournal of the Mechanical Behavior of Biomedical Materials
PublisherData powered by TypesetElsevier Ltd
ISSN17516161
Open AccessNo
Concepts (56)
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    Biocompatibility
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    Biodegradability
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    Biomaterials
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    Chitosan
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    Crosslinking
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    Dynamic loads
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    Dynamic mechanical analysis
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    Dynamics
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    Hydroxyapatite
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    Mechanical properties
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    Mechanisms
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    Molecular dynamics
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    Nanocomposites
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    Nanoindentation
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    Nanoparticles
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    PARTICLE REINFORCED COMPOSITES
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    Reinforcement
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    Stress analysis
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    Stress relaxation
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    Viscoelasticity
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    Dynamic loading conditions
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    GENERALIZED MAXWELL MODEL
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    NANO-DMA
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    NANO-SCRATCH
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    NANOMECHANICAL
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    NANOMECHANICAL CHARACTERIZATION
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    PARTICLE REINFORCEMENT
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    STRESS RELAXATION BEHAVIOR
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    Nanocomposite films
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    Biopolymer
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    Nanoparticle
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    TRIPOLYPHOSPHATE
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    Analysis
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    Article
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    Biomechanics
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    Cross linking
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    Ductility
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    Hardness
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    Hydrogen bond
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    MAXWELL MODEL
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    Molecular mechanics
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    Priority journal
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    Static electricity
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    Statistical model
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    Stress strain relationship
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    YOUNG MODULUS
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    Chemical structure
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    Chemistry
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    Conformation
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    Materials testing
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    Mechanics
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    Nanotechnology
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    Carbohydrate conformation
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    Elastic modulus
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    Mechanical processes
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    Models, molecular