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MutHTP: Mutations in human transmembrane proteins
A. Kulandaisamy, S. Binny Priya, Ramasamy Sakthivel,
Published in Oxford University Press
PMID: 29401218
Volume: 34
Issue: 13
Pages: 2325 - 2326
Motivation: Existing sources of experimental mutation data do not consider the structural environment of amino acid substitutions and distinguish between soluble and membrane proteins. They also suffer from a number of further limitations, including data redundancy, lack of disease classification, incompatible information content, and ambiguous annotations (e.g. the same mutation being annotated as disease and benign). Results: We have developed a novel database, MutHTP, which contains information on 183 395 disease-associated and 17 827 neutral mutations in human transmembrane proteins. For each mutation site MutHTP provides a description of its location with respect to the membrane protein topology, structural environment (if available) and functional features. Comprehensive visualization, search, display and download options are available. © The Author(s) 2018. Published by Oxford University Press. All rights reserved.
About the journal
JournalData powered by TypesetBioinformatics
PublisherData powered by TypesetOxford University Press
Open AccessNo
Concepts (9)
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    Membrane protein
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    Factual database
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    Databases, factual
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    Membrane proteins