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Modeling and simulation of xylitol production in bioreactor by Debaryomyces nepalensis NCYC 3413 using unstructured and artificial neural network models
J. Sharon Mano Pappu,
Published in Elsevier Ltd
2016
PMID: 27611032
Volume: 220
   
Pages: 490 - 499
Abstract
This study examines the use of unstructured kinetic model and artificial neural networks as predictive tools for xylitol production by Debaryomyces nepalensis NCYC 3413 in bioreactor. An unstructured kinetic model was proposed in order to assess the influence of pH (4, 5 and 6), temperature (25 °C, 30 °C and 35 °C) and volumetric oxygen transfer coefficient kLa (0.14 h−1, 0.28 h−1 and 0.56 h−1) on growth and xylitol production. A feed-forward back-propagation artificial neural network (ANN) has been developed to investigate the effect of process condition on xylitol production. ANN configuration of 6-10-3 layers was selected and trained with 339 experimental data points from bioreactor studies. Results showed that simulation and prediction accuracy of ANN was apparently higher when compared to unstructured mechanistic model under varying operational conditions. ANN was found to be an efficient data-driven tool to predict the optimal harvest time in xylitol production. © 2016 Elsevier Ltd
About the journal
JournalData powered by TypesetBioresource Technology
PublisherData powered by TypesetElsevier Ltd
ISSN09608524
Open AccessNo
Concepts (56)
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    Backpropagation
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    Bioconversion
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    Bioreactors
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    Forecasting
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    Kinetic parameters
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    Kinetic theory
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    Neural networks
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    Artificial neural network models
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    DATA-DRIVEN MODEL
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    FEED-FORWARD BACK PROPAGATION
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    Operational conditions
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    UNSTRUCTURED KINETIC MODEL
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    UNSTRUCTURED MODEL
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    VOLUMETRIC OXYGEN TRANSFER COEFFICIENT
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    XYLITOL
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    Sugar substitutes
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    Oxygen
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    XYLITOL
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    XYLITOL
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    Artificial neural network
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    BIOLOGICAL PRODUCTION
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    Bioreactor
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    Numerical model
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    Operations technology
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    Organic compound
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    Prediction
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    Reaction kinetics
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    Simulation
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    Yeast
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    Article
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    BATCH FERMENTATION
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    Batch reactor
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    DEBARYOMYCES
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    DEBARYOMYCES NEPALENSIS
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    HARVEST PERIOD
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    Kinetics
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    Nonhuman
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    pH
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    Priority journal
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    Temperature
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    VOLUMETRY
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    Batch cell culture
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    Biosynthesis
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    Budding yeast
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    Computer simulation
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    Growth, development and aging
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    Metabolism
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    Microbiology
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    Theoretical model
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    DEBARYOMYCES NEPALENSIS
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    Batch cell culture techniques
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    Hydrogen-ion concentration
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    Models, theoretical
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    Neural networks (computer)
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    Saccharomycetales
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    XYLITOL