We discuss the role of the metal-ligand (M-L) interfaces in the chemistry of ligand-protected, atomically precise noble metal clusters, a new and expanding family of nanosystems, in solution as well as in the gas phase. A few possible mechanisms by which the structure and dynamics of M-L interfaces could trigger intercluster exchange reactions are presented first. How interparticle chemistry can be a potential mechanism of Ostwald ripening, a well-known particle coarsening process, is also discussed. The reaction of Ag59(2,5-DCBT)32 (DCBT = dichlorobenzenethiol) with 2,4-DCBT leading to the formation of Ag44(2,4-DCBT)30 is presented, demonstrating the influence of the ligand structure in ligand-induced chemical transformations of clusters. We also discuss the structural isomerism of clusters such as Ag44(SR)30 (-SR = alkyl/aryl thiolate) in the gas phase wherein the occurrence of isomerism is attributed to the structural rearrangements in the M-L bonding network. Interfacial bonding between Au25(SR)18 clusters leading to the formation of cluster dimers and trimers is also discussed. Finally, we show that the desorption of phosphine and hydride ligands on a silver cluster, [Ag18(TPP)10H16]2+ (TPP = triphenylphosphine) in the gas phase, leads to the formation of a naked silver cluster of precise nuclearity, such as Ag17 +. We demonstrate that the nature of the M-L interfaces, i.e., the oxidation state of metal atoms, structure of the ligand, M-L bonding network, and so forth, plays a key role in the chemical reactivity of clusters. The structure, dynamics, and chemical reactivity of nanosystems in general are to be explored together to obtain new insights into their emerging science. Copyright © 2018 American Chemical Society.