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Metal free synthesis of α-keto amides from 2-hydroxy acetophenones through domino alcohol oxidation-oxidative amidation reaction
Surya Srinivas Kotha,
Published in Elsevier Ltd
2015
Volume: 56
   
Issue: 46
Pages: 6323 - 6326
Abstract
An efficient method for the synthesis of α-keto amides using 2-iodoxybenzoic acid (IBX) promoted domino alcohol oxidation and oxidative amidation reaction sequence between 2-oxoalcohols and amines under metal-free conditions is developed. In this protocol, IBX is used as an oxidizing agent to synthesize the α-keto amides, which makes this methodology highly efficient, practical, and environmentally benign. © 2015 Elsevier Ltd. All rights reserved.
About the journal
JournalData powered by TypesetTetrahedron Letters
PublisherData powered by TypesetElsevier Ltd
ISSN00404039
Open AccessNo
Concepts (16)
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    Acetophenone derivative
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    Alcohol derivative
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    Aldehyde
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    Amide
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    Amine
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    Metal
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    Oxidizing agent
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    Alcohol oxidation
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    Amidation
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    Article
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    Chemical structure
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    Controlled study
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    Methodology
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    Reaction analysis
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    Solubility
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    Synthesis