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Metal free one pot synthesis of Β-carbolines via a domino Pictet-Spengler reaction and aromatization
Kalapattukuppuswamy Kuppuswamy B. Balasubramanian
Published in Elsevier B.V.
2019
Volume: 468
   
Pages: 86 - 93
Abstract
A convenient and efficient metal free, atom economical flexible synthesis of β-carbolines involving a domino Pictet-Spengler reaction and aromatization in oxygen atmosphere in N-methyl-2-pyrollidone (NMP) is described. Variety of aryl, heteroaryl and aliphatic aldehydes were found to be good substrates for this methodology. Several β-carbolines (6a-6t) and β-carboline methyl esters (7a-7e) were synthesized using this methodology.The same reaction carried out in argon atmosphere in the presence of catalytic amount of acid in NMP furnished, tetrahydro-β-carbolines (4a-4g). © 2019 Elsevier B.V.
About the journal
JournalData powered by TypesetMolecular Catalysis
PublisherData powered by TypesetElsevier B.V.
ISSN24688231
Open AccessNo
Concepts (11)
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    Aromatization
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    Reaction kinetics
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    Aliphatic aldehydes
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    CARBOLINES
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    Catalytic amounts
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    CYLIZATION
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    Domino reactions
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    One-pot synthesis
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    Oxygen atmosphere
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    Pictet-spengler reactions
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    Pyridine