Header menu link for other important links
Metal free one pot synthesis of Β-carbolines via a domino Pictet-Spengler reaction and aromatization
Kalapattukuppuswamy Kuppuswamy B. Balasubramanian
Published in Elsevier B.V.
Volume: 468
Pages: 86 - 93
A convenient and efficient metal free, atom economical flexible synthesis of β-carbolines involving a domino Pictet-Spengler reaction and aromatization in oxygen atmosphere in N-methyl-2-pyrollidone (NMP) is described. Variety of aryl, heteroaryl and aliphatic aldehydes were found to be good substrates for this methodology. Several β-carbolines (6a-6t) and β-carboline methyl esters (7a-7e) were synthesized using this methodology.The same reaction carried out in argon atmosphere in the presence of catalytic amount of acid in NMP furnished, tetrahydro-β-carbolines (4a-4g). © 2019 Elsevier B.V.
About the journal
JournalData powered by TypesetMolecular Catalysis
PublisherData powered by TypesetElsevier B.V.
Open AccessNo
Concepts (11)
  •  related image
  •  related image
    Reaction kinetics
  •  related image
    Aliphatic aldehydes
  •  related image
  •  related image
    Catalytic amounts
  •  related image
  •  related image
    Domino reactions
  •  related image
    One-pot synthesis
  •  related image
    Oxygen atmosphere
  •  related image
    Pictet-spengler reactions
  •  related image