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Retinoblastoma (RB) is a childhood eye cancer. Currently, chemotherapy, local therapy, and enucleation are the main ways in which these tumors are managed. The present work is the first study that uses constraint-based reconstruction and analysis approaches to identify and explain RB-specific survival strategies, which are RB tumor specific. Importantly, our model-specific secretion profile is also found in RB1-depleted human retinal cells in vitro and suggests that novel biomarkers involved in lipid metabolism may be important. Finally, RB-specific synthetic lethals have been predicted as lipid and nucleoside transport proteins that can aid in novel drug target development. © 2018 Federation of European Biochemical Societies
View more info for "Metabolite systems profiling identifies exploitable weaknesses in retinoblastoma."
Journal | Data powered by TypesetFEBS Letters |
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Publisher | Data powered by TypesetWiley Blackwell |
ISSN | 00145793 |
Open Access | No |