The quest for novel kinetic promoters for efficient storage and safe transportation of natural gas in the form of hydrates is an ongoing endeavor. In this study, the kinetics of methane hydrate formation have been investigated in the presence of low-foaming, nonionic, 1-dodecyl-2-pyrrolidinone and tetrahydrofuran in aqueous solution in a stirred tank reactor. The first phase of experiments has been conducted at 5 MPa and 274.15 K with varying concentrations of 1-dodecyl-2-pyrrolidinone (0.1, 0.5, 1, and 2 wt %). Similarly, the second phase of experiments has been conducted with two different concentrations of THF (19.49 and 3.89 wt %) along with 0.5 and 2 wt % of 1-dodecyl-2-pyrrolidinone using methane gas as the hydrate former at 5 MPa and 282.55 K. The pressure and temperature conditions are chosen covering both sI and sII regions. Information on the number of moles of gas consumed during hydrate formation, induction time, water-to-hydrate/gas-to-hydrate conversion, and gas storage capacity are investigated. It is observed that 1-dodecyl-2-pyrrolidinone shows good hydrate promotion characteristics with pure water for all the selected concentrations, with 0.5 wt % being on the higher side. Also, it has been observed that 1-dodecyl-2-pyrrolidinone serves as an effective kinetic promoter for the mixed methane-tetrahydrofuran hydrate at a moderate pressure and temperature of 5 MPa and 282.55 K. This study will assist in storing multifold volumes of natural gas in compact hydrate crystals suitable for natural gas storage and transportation applications. © 2021 American Chemical Society.