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KIBRA connects Hippo signaling and cancer
Swaroop B S.S., Kanumuri R., Ezhil I., Naidu Sampangi J.K., Kremerskothen J., , Venkatraman G.
Published in
2021
Volume: 403
   
Issue: 2
Abstract
The Hippo signaling pathway is a tumor suppressor pathway that plays an important role in tissue homeostasis and organ size control. KIBRA is one of the many upstream regulators of the Hippo pathway. It functions as a tumor suppressor by positively regulating the core Hippo kinase cascade. However, there are accumulating shreds of evidence showing that KIBRA has an oncogenic function, which we speculate may arise from its functions away from the Hippo pathway. In this review, we have attempted to provide an overview of the Hippo signaling with a special emphasis on evidence showing the paradoxical role of KIBRA in cancer. © 2021 Elsevier Inc.
About the journal
JournalExperimental Cell Research
Open AccessNo