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KIBRA; a novel biomarker predicting recurrence free survival of breast cancer patients receiving adjuvant therapy
Published in BioMed Central Ltd.
2018
PMID: 29793439
Volume: 18
   
Issue: 1
Abstract
Background: This study was carried out to evaluate the prognostic value of KIBRA in breast cancer. Methods: This retrospective study included breast cancer patients who sought the services of the immunohistochemistry laboratory of our unit from 2006 to 2015. Tissue microarrays were constructed and immunohistochemical staining was done to assess the KIBRA expression. The Kaplan-Meier model for univariate and Cox-regression model with backward stepwise factor retention method for multivariate analyses were used. Chi square test was used to find out the associations with the established prognostic features. Results: A total of 1124 patients were included in the study and KIBRA staining of 909 breast cancers were available for analysis. Cytoplasmic KIBRA expression was seen in 39.5% and nuclear expression in 44.8%. Overall KIBRA-low breast cancers accounted for 41.5%. KIBRA nuclear expression was significantly associated with positive ER and PR expression. Luminal breast cancer patients who had endocrine therapy and KIBRA-low expression had a RFS disadvantage over those who were positive for KIBRA (p = 0.02). Similarly, patients who received chemotherapy and had overall KIBRA-low expression also demonstrated a RFS disadvantage compared to those who had overall positive KIBRA expression (p = 0.018). This effect of KIBRA was independent of the other factors considered for the model. Conclusion: Overall low-KIBRA expression has an independent effect on the RFS and predicts the RFS outcome of luminal breast cancer patients who received endocrine therapy and breast cancer patients who received chemotherapy. © 2018 The Author(s).
About the journal
JournalBMC Cancer
PublisherBioMed Central Ltd.
ISSN14712407
Open AccessYes
Concepts (69)
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    Estrogen receptor
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    KI 67 ANTIGEN
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    PROGESTERONE RECEPTOR
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    TRASTUZUMAB
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    PHOSPHOPROTEIN
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    PROGESTERONE RECEPTOR
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    Signal peptide
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    Tumor marker
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    WWC1 PROTEIN, HUMAN
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    Adult
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    Article
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    Breast cancer
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    Cancer adjuvant therapy
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    Cancer chemotherapy
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    CANCER HORMONE THERAPY
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    CANCER PROGNOSIS
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    Cancer recurrence
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    Cancer survival
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    Cell nucleus
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    Cohort analysis
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    Controlled study
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    Cross-sectional study
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    Cytoplasm
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    DESCRIPTIVE RESEARCH
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    Female
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    FOLLOW UP
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    Gene
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    Human
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    Human cell
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    HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2 POSITIVE BREAST CANCER
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    Human tissue
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    Immunohistochemistry
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    KIBRA GENE
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    LUMINAL B BREAST CANCER
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    Major clinical study
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    Male
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    MASTECTOMY
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    Protein expression
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    RECURRENCE FREE SURVIVAL
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    Retrospective study
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    Tissue microarray
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    Triple negative breast cancer
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    Adjuvant chemotherapy
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    BREAST
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    Breast tumor
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    Diagnosis
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    DISEASE FREE SURVIVAL
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    Evaluation study
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    KAPLAN MEIER METHOD
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    Metabolism
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    Middle aged
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    Mortality
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    Pathology
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    Prognosis
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    TUMOR RECURRENCE
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    BIOMARKERS, TUMOR
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    BREAST
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    Breast neoplasms
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    Chemotherapy, adjuvant
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    Cross-sectional studies
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    DISEASE-FREE SURVIVAL
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    Humans
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    Intracellular signaling peptides and proteins
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    KAPLAN-MEIER ESTIMATE
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    NEOPLASM RECURRENCE, LOCAL
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    Phosphoproteins
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    Receptors, estrogen
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    RECEPTORS, PROGESTERONE
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    Retrospective studies