An ironO-catalyzed (TEMPO = 2,2,6,6-tetramethyl-1-piperidinyloxy), aerobic process was developed to synthesize α-keto amides. This reaction proceeds through a domino alcohol oxidation/oxidative cross-dehydrogenative coupling sequence, uses 2-hydroxyacetophenones and amines as the starting materials, and takes place under molecular oxygen, which makes the transformation highly efficient, practical, and environmentally friendly. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Govindasamy Sekar

Department Of Chemistry

Surya Srinivas Kotha

Selvaraj Chandrasekar

IIT Madras is a public technical and research university located in Chennai, Tamil Nadu. Founded in 1959, it is recognised as an Institute of National Importance.

IIT Madras has been ranked as the top engineering institute in India for four years in a row by the National Institutional Ranking Framework of the MHRD

It currently offers undergraduate, postgraduate and research degrees across 16 disciplines in Engineering, Sciences, Humanities and Management. About 596 faculty belonging to science and engineering departments and centres of the Institute are engaged in teaching, research and industrial consultancy.

IIT Madras

European Journal of Organic Chemistry

A practical approach towards the synthesis of α-ketoamides from readily available terminal alkenes (styrenes) has been developed. Use of inexpensive I<inf>2</inf>/2-iodoxybenzoic acid (IBX) in dimethyl sulphoxide (DMSO) as an oxidant under metal free one-pot conditions makes this methodology versatile. © The Royal Society of Chemistry 2015.

RSC Advances

Metal free one-pot synthesis of α-ketoamides from terminal alkenes

An efficient, economic and environmentally friendly enantioselective oxidation of racemic benzoins (α-hydroxy ketones) catalyzed by a chiral iron complex has been developed using molecular oxygen as a terminal oxidant with good selectivity and excellent enantiomeric excess. © 2009 The Royal Society of Chemistry.

Chemical Communications

Chiral iron complex catalyzed enantioselective oxidation of racemic benzoins

Journal of the American Chemical Society

Mechanism of Alcohol Oxidation Mediated by Copper(II) and Nitroxyl Radicals

Angewandte Chemie International Edition

Transition-Metal-Free Aerobic Oxidative Cleavage of CC Bonds in α-Hydroxy Ketones and Mechanistic Insight to the Reaction Pathway

Organic Letters

Copper-Catalyzed Aerobic Oxidative Cross-Dehydrogenative Coupling of Amine and α-Carbonyl Aldehyde: A Practical and Efficient Approach to α-Ketoamides with Wide Substrate Scope

Spotlights on our sister journals: Angew. Chem. Int. Ed. 6/2012

IronO-Catalyzed Domino Aerobic Alcohol Oxidation/Oxidative Cross-Dehydrogenative Coupling for the Synthesis of α-Keto Amides

Journal	Data powered by TypesetEuropean Journal of Organic Chemistry
Publisher	Data powered by TypesetWiley-VCH Verlag
ISSN	1434193X
Open Access	No