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Iron-catalyzed direct synthesis of amides from methylarenes
Sindhura Badigenchala,
Published in Wiley-VCH Verlag
Volume: 357
Issue: 7
Pages: 1437 - 1445
An efficient, green and first catalytic process has been developed for the direct synthesis of amides from readily available petroleum by-products (methylarenes) and amines using an iron catalyst. In this new catalytic reaction, the methyl group of the methylarene is oxidized to the corresponding aldehyde through non-directed C-(sp-3)-H oxidation followed by its oxidative amidation with N-chloroamine, yielding the carboxylic amide. Oxidation with an iron catalyst, tert-butyl hydroperoxide (TBHP) as sole oxidant, the synthesis of amides under mild reaction conditions and the utilization of methylarenes as starting material make this methodology novel and environmentally benign. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
About the journal
JournalData powered by TypesetAdvanced Synthesis and Catalysis
PublisherData powered by TypesetWiley-VCH Verlag
Open AccessNo