Radio Frequency (RF) heating of Gold nanoparticles (GNPs) for hyperthermia is presented. RF heating experimental study was carried out at 915 MHz for phosphate buffer solution (PBS) with and without 10 nm GNPs in muscle phantom. Influence of GNPs on radiated heating was investigated for 10 and 20 W input power. The phantom heating rate was similar for the control (only PBS) and PBS with GNPs. Experimental results showed that the buffer solution with and without the GNPs heated alike indicating no enhancement in RF heating. © 2019 URSI. All rights reserved.