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Immobilization of hyaluronic acid from Lactococcus lactis on polyethylene terephthalate for improved biocompatibility and drug release
Balaji Ramachandran, Sudip Chakraborty, Ramya Kannan, ,
Published in Elsevier Ltd
2019
PMID: 30553306
Volume: 206
   
Pages: 132 - 140
Abstract
Hyaluronic acid from metabolically engineered Lactococcus lactis (HAL) was characterized for its biocompatibility and immobilized on the polyethylene terephthalate (PET) surface. HAL was chemically crosslinked on hydrolyzed PET (hPET) surface to form HAL-coated PET (hPET-HAL). The unmodified and modified PET were characterized by Fourier-transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), contact angle measurement, thermogravimetric analysis (TGA), universal testing machine (UTM) and assessed for their biocompatibility. FT-IR confirmed the successful immobilization of HAL on the hPET surface. HAL coating significantly improved the haemocompatibility compared to hPET and unmodified PET. Endothelial cell attachment was significantly improved on hPET-HAL and hPET surfaces compared to the unmodified PET. Model drugs (aspirin and methylene blue) were loaded into the HAL matrix, and showed complete release at around 18 h. These results confirm that covalent attachment of HAL matrix on PET surfaces is a promising strategy for developing drug-eluting implants with enhanced haemocompatibility and endothelialization. © 2018 Elsevier Ltd
About the journal
JournalData powered by TypesetCarbohydrate Polymers
PublisherData powered by TypesetElsevier Ltd
ISSN01448617
Open AccessNo
Concepts (46)
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    Aromatic compounds
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    Biocompatibility
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    Contact angle
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    Controlled drug delivery
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    Endothelial cells
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    Fourier transform infrared spectroscopy
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    Hyaluronic acid
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    Organic acids
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    Polyethylene terephthalates
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    Scanning electron microscopy
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    Surface treatment
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    Targeted drug delivery
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    Thermogravimetric analysis
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    COVALENT ATTACHMENT
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    Drug release
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    ENDOTHELIALIZATION
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    Fourier transform infra red (ftir) spectroscopy
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    Haemocompatibility
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    LACTOCOCCUS LACTIS
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    POLYETHYLENE TEREPHTHALATES (PET)
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    Universal testing machines
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    Plastic bottles
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    ACETYLSALICYLIC ACID
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    Biomaterial
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    Methylene blue
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    POLYETHYLENE TEREPHTHALATE
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    Animal
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    Chemistry
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    Endothelium cell
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    Human
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    Kinetics
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    LACTOCOCCUS LACTIS
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    Metabolism
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    Mouse
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    Nih 3t3 cell line
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    Wettability
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    YOUNG MODULUS
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    Animals
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    Aspirin
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    Biocompatible materials
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    Drug liberation
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    Elastic modulus
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    Humans
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    LACTOCOCCUS LACTIS
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    Mice
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    Nih 3t3 cells