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Identifying a potential receptor for the antibacterial peptide of sponge Axinella donnani endosymbiont
Chandrasekaran Ramakrishnan,
Published in Elsevier
2015
PMID: 25939848
Volume: 566
   
Issue: 2
Pages: 166 - 174
Abstract
Marine sponges and their associated bacteria are rich sources of novel secondary metabolites with therapeutic usefulness. In our earlier work, we have identified a novel antibacterial peptide from the marine sponge Axinella donnani endosymbiotic bacteria. In this work, we have carried out a comparative genomic analysis and identified a set of 60 proteins as probable receptor which is common in all the strains. The analysis on binding substrate showed that β barrel assembly machinery (BamA) of the outer membrane protein 85 (omp85) superfamily is a potential receptor protein for the antibacterial peptide. It plays a central role in OMP biogenesis, especially in cell viability. Further, the triplet and quartet motifs RGF and YGDG, respectively in L6 loop are conserved over all the strains and these conserved residues interact with antibacterial peptide to inhibit the BamA function, which is essential for OMP biogenesis. © 2015 Elsevier B.V.
About the journal
JournalData powered by TypesetGene
PublisherData powered by TypesetElsevier
ISSN03781119
Open AccessNo
Concepts (52)
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    DNA
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    Outer membrane protein
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    OUTER MEMBRANE PROTEIN 85
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    Polypeptide antibiotic agent
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    RECEPTOR PROTEIN
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    RIBOSOME RNA
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    Transfer rna
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    Unclassified drug
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    Antiinfective agent
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    Cell surface receptor
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    Peptide
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    Aliivibrio fischeri
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    Article
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    AXINELLA
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    Bacillus cereus
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    Bacterium
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    ENDOSYMBIONT
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    Escherichia coli
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    Genome
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    Genomics
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    Human
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    MARINE SPECIES
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    Metabolite
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    Molecular dynamics
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    Molecular evolution
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    Nonhuman
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    Peptide analysis
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    Priority journal
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    Protein assembly
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    Protein structure
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    Pseudomonas
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    SHRIMP
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    VIBRIO ALGINOLYTICUS
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    VIBRIO HARVEYI
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    Amino acid sequence
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    Animal
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    Chemistry
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    Metabolism
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    Microbiology
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    Molecular genetics
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    Phylogeny
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    Sequence homology
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    SPONGE (PORIFERA)
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    Symbiosis
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    AXINELLA DONNANI
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    Animals
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    Anti-bacterial agents
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    Molecular sequence data
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    Peptides
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    PORIFERA
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    Receptors, cell surface
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    Sequence homology, amino acid