Two hybrid PWM methods are proposed in this paper for a pump drive based on three-level Neutral-Point Clamped (NPC) inverter. The envisaged PWM methods are aimed at reducing output voltage harmonic distortion. While the first PWM method incorporates suitable voltage injection to the carrier signals, the second PWM method incorporates voltage injection to both carrier and the modulating signals for controlling the NPC drive. Detailed harmonic analysis is presented using Double Fourier Integral Approach (DFIA) for both the hybrid PWM methods by separately identifying their basic unit cells, their boundaries that demarcates different regions of inverter drive. Complete analytical expressions for dc, fundamental, carrier and side-band harmonic components present in the output voltage of the NPC drive are presented for both the hybrid PWM methods. The proposed PWM methods are simulated using Matlab/Simulink and are experimentally validated using an induction motor driven pump load, following V/f control. Superiority of the hybrid PWM methods in comparison to the existing PWM methods are demonstrated with vTHD, weighted THD (vWTHD), iTHD, harmonic loss factor etc., supporting the envisaged PWM methods. © 2021 Taylor & Francis Group, LLC.