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Hopping-mediated anion transport through a mannitol-based rosette ion channel
Published in American Chemical Society
2014
PMID: 25203165
Volume: 136
   
Issue: 40
Pages: 14128 - 14135
Abstract
Artificial anion selective ion channels with single-file multiple anion-recognition sites are rare. Here, we have designed, by hypothesis, a small molecule that self-organizes to form a barrel rosette ion channel in the lipid membrane environment. Being amphiphilic in nature, this molecule forms nanotubes through intermolecular hydrogen bond formation, while its hydrophobic counterpart is stabilized by hydrophobic interactions in the membrane. The anion selectivity of the channel was investigated by fluorescence-based vesicle assay and planar bilayer conductance measurements. The ion transport by a modified hopping mechanism was demonstrated by molecular dynamics simulation studies. © 2014 American Chemical Society.
About the journal
JournalData powered by TypesetJournal of the American Chemical Society
PublisherData powered by TypesetAmerican Chemical Society
ISSN00027863
Open AccessNo
Concepts (43)
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    Hydrogen bonds
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    Hydrophobicity
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    Molecular dynamics
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    Molecules
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    Yarn
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    ANION SELECTIVITY
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    ANION TRANSPORT
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    Conductance measurement
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    HOPPING MECHANISM
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    Hydrophobic interactions
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    INTERMOLECULAR HYDROGEN BONDS
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    Molecular dynamics simulations
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    RECOGNITION SITE
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    Ions
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    Ion channel
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    MANNITOL
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    Biomimetic material
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    Hydroxide
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    HYDROXIDE ION
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    MANNITOL
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    ANION TRANSPORT
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    Article
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    Fluorescence
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    Hydrogen bond
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    Mass spectrometry
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    Molecular stability
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    ROSETTE FORMATION
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    Binding site
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    Cell membrane
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    Chemical structure
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    Chemistry
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    Conformation
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    Ion transport
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    Metabolism
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    Thermodynamics
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    Binding sites
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    Biomimetic materials
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    Hydrogen bonding
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    Hydroxides
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    Ion channels
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    MANNITOL
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    Models, molecular
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    Molecular conformation