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Highly stereoselective chlorination of β-substituted cyclic alcohols using PPh3-NCS: Factors that control the stereoselectivity
Sreehari S. Kumar, R. Koteshwar Rao, Krishna Gopal Thakur,
Published in
2007
   
Issue: 8
Pages: 867 - 869
Abstract
A variety of trans-β-substituted cyclic alcohols were stereoselectively chlorinated to either the corresponding cis-chloride or trans-chloride (inversion or retention of configuration) with good to excellent yields; the stereochemical outcome is determined by the size of the ring and the nature of the β-substituents, especially the electronegativity of the substituted atom. © The Royal Society of Chemistry.
About the journal
JournalChemical Communications
ISSN13597345
Open AccessNo
Concepts (13)
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    Alcohol derivative
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    Chloride
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    N CHLOROSUCCINIMIDE
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    PHOSPHOPROTEIN PHOSPHATASE
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    Succinimide derivative
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    Unclassified drug
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    Article
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    Chemical reaction
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    Chlorination
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    Electron
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    Halogenation
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    NEIGHBOR JOINING METHOD
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    Stereochemistry