Header menu link for other important links
X
Halogenative kinetic resolution of β-amido alcohols: Chiral BINAP-mediated SN2 displacement of hydroxy groups by chlorides with inversion of stereochemistry
Published in Elsevier Ltd
2010
Volume: 21
   
Issue: 7
Pages: 780 - 785
Abstract
A series of optically active cyclic trans-β-amido alcohols were obtained by the non-enzymatic kinetic resolution of the corresponding racemic amido alcohols using commercially available (S)-BINAP and NCS by SN2 halogenation of the hydroxy group. The product, cis-β-amido chloride, was also obtained in optically active form with an inversion of stereochemistry. © 2010 Elsevier Ltd. All rights reserved.
About the journal
JournalData powered by TypesetTetrahedron Asymmetry
PublisherData powered by TypesetElsevier Ltd
ISSN09574166
Open AccessNo
Concepts (17)
  •  related image
    1,1' BINAPHTHYL DERIVATIVE
  •  related image
    Alcohol derivative
  •  related image
    Amide
  •  related image
    Chloride
  •  related image
    Hydroxyl group
  •  related image
    Phosphine derivative
  •  related image
    Succinimide derivative
  •  related image
    Article
  •  related image
    Chemical reaction
  •  related image
    Chemical structure
  •  related image
    Chirality
  •  related image
    Enzyme kinetics
  •  related image
    Halogenation
  •  related image
    Priority journal
  •  related image
    Racemic mixture
  •  related image
    Reaction analysis
  •  related image
    Stereochemistry