A numerical model was used to investigate gas-phase entropy generation during transient methanol droplet combustion in a low-pressure, zero-gravity, air environment.A comprehensive formulation for the entropy generation in a multi-component reacting flow is derived. Stationary methanol droplet combustion in a low ambient temperature (300 K) and a nearly quiescent atmosphere was studied and the effect of surface tension on entropy generation is discussed. Results show that the average entropy generation rate over the droplet lifetime is higher for the case that neglects surface tension. Entropy generation during the combustion of methanol droplets moving in a high-temperature environment (1200 K), as seen in a typical spray combustion system, is also presented. Entropy generation due to chemical reaction increases and entropy generation due to heat and mass transfer decreases with an increase in initial Reynolds number over the range of initial Reynolds numbers (1-100) considered. Contributions due to heat transfer and chemical reaction to the total entropy generation are greater than the contribution due to mass transfer. Entropy generation due to coupling between heat and mass transfer is negligible. For moving droplets, the lifetime averaged entropy generation rate presents a minimum value at an initial Reynolds number of approximately 55. © 2010 Elsevier Masson SAS. All rights reserved.