Wettability plays an important role during flow boiling inside micro and mini channels. The present work focuses on the flow boiling heat transfer characteristics inside copper minitube (inner diameter of 3 mm) coated internally to render the inside surface nearly hydrophobic. Electroless Galvanic Deposition technique is employed for hydrophobic coating inside the copper tube. Both single phase heat transfer and two-phase flow boiling heat transfer and pressure drop characteristics were investigated in regular and internally coated hydrophobic copper minitubes. The experiments were performed with deionized water as a working fluid and the mass flux was varied from 100 to 650 kg/m2s. The two-phase heat transfer characteristics was observed to be both functions of mass flux as well as heat flux. The two phase heat transfer has been observed to be augmented due to the wettability within the tubes. The two-phase pressure drop has also been observed to increase when compared to the regular, uncoated tube; however, the proportional increment is lower than the augmentation achieved in two-phase heat transfer. The enhanced heat transfer effects observed have been explained on the basis of wetting physics. © 2019, © 2019 Taylor & Francis Group, LLC.