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Fischer indole synthesis in low melting mixtures
Sangram Gore,
Published in
2012
PMID: 22905733
Volume: 14
   
Issue: 17
Pages: 4568 - 4571
Abstract
Functionalized indoles are synthezised under mild conditions in a tartaric acid-dimethylurea melt. The melt serves as the solvent and as the catalyst. Under these reaction conditions, sensitive functional groups such as N-Boc, N-Cbz, or azides are stable, and indolenines are obtained regioselectively in excellent yields. The practical use of the method is demonstrated in the synthesis of the hormone melatonin. © 2012 American Chemical Society.
About the journal
JournalOrganic Letters
ISSN15237060
Open AccessNo
Concepts (16)
  •  related image
    Fused heterocyclic rings
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    Indole derivative
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    Article
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    Catalysis
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    Chemical structure
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    Chemistry
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    Combinatorial chemistry
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    Methodology
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    Organic chemistry
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    Stereoisomerism
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    Synthesis
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    Chemistry, organic
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    Combinatorial chemistry techniques
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    Heterocyclic compounds, 3-ring
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    Indoles
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    Molecular structure