Header menu link for other important links
Fabrication of TiO2 micro-spikes and micro-flowers for massively parallel intracellular delivery
L. Mohan, S. Kar, Nandhini B., Gupta P., Shinde P., ,
Published in Chemical and Biological Microsystems Society
Pages: 1210 - 1211
Treating critical diseases in recent years demand significant research on intracellular delivery in the field of medical science and cell biology. The ability to deliver external molecules into living cells with high transfection efficiency and cell viability is of great interest in cell biology for applications in therapeutic development, diagnostics, and drug delivery. In the present work, we demonstrated Titanium-di-oxide (TiO2) microstructure-based (micro-spikes (MS) and micro-flowers (MF)) photoporation platform for versatile and highly efficient intracellular delivery, which is potentially applicable for cellular therapy and diagnostics. Due to exposure of nanosecond pulse laser, transient hydrophilic membrane pores forms on the cell membrane and cargo gently deliver into cells. The best result was achieved using Propidium iodide (PI) dye with high delivery efficiency and cell viability for HCT-116 cell line. © 2019 CBMS-0001.
About the journal
Journal23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PublisherChemical and Biological Microsystems Society
Open AccessNo