The present work focuses on two phase heat transfer and flow boiling pressure drop in a horizontal circular minitube with deionized water as a working fluid. The experiments were conducted in a 316 stainless steel tube with 1.21 mm inside diameter and a heated length of 276 mm. The present study analyzed the two phase heat transfer and two phase pressure drop at various values of mass flux and heat flux. The operating parameters used were mass flux from 1077 kg/m2s to 1915 kg/m2s and degree of inlet subcooling of 30 °C, 35 °C, 40 °C with heat flux from 20 to 200 kW/m2. The experimental results of two phase heat transfer coefficient were compared with micro-scale and conventional correlations from the literature. It was found that the heat transfer is distinctly different from those predicted by conventional correlations and is closer to minichannel correlations available in the literature.