An increased use of thermoplastics in components and structures that are subjected to cyclic loads necessitates a specific attention to variables that affect the hysteretic heating. Hysteretic heating effect in polyamide 66/hectorite nanocomposite has been investigated under bending strain control mode using a custom-built bending fatigue test setup in a laboratory environment. Dynamic mechanical analysis (DMA) results revealed a considerable rise in loss modulus with a decrease in frequency from 1 to 0.1 Hz irrespective of the temperature of the specimen. Alternatively, a reduction in fatigue test frequency from 2 to 0.5 Hz resulted in a significant decrease in cyclic softening. Fatigue behaviour predicted from DMA results using coupled structural/thermal finite element analysis is fairly in agreement with the experimental one. An accelerated crack initiation at decreased specimen temperature and high cyclic steady state stress reduced the fatigue life at 0.5 Hz compared with 2 Hz. © 2018, © 2018 Institute of Materials, Minerals and Mining Published by Taylor & Francis on behalf of the Institute.