ACS Sustainable Chemistry & Engineering (ACS SCE) reports and promotes innovation and advances in sustainable chemistry and engineering. The disciplines of sustainable chemistry and engineering are rapidly evolving, and consequently, so are our expectations for manuscripts to be published in ACS SCE. To help and guide authors in understanding these changes, this Editorial seeks to define the scope and standard for manuscripts reporting advances in catalysis and catalytic processes that promote resource-efficient conversion of various types of feedstocks to desired products. At the core of sustainable chemistry and engineering is the development of catalytic processes that conserve material and energy resources, minimize adverse environmental footprints, including greenhouse gas emissions, and avoid the reliance on toxic and hazardous compounds. This involves manipulating the structure and composition of catalysts, possibly with atomic precision, leading to enhanced efficiency in their functions.