Header menu link for other important links
X
Evidence for altered structure and impaired mitochondrial electron transport function in selenium deficiency
Kalyanaraman Lalitha
Published in Humana Press Inc.
1996
PMID: 8727670
Volume: 51
   
Issue: 3
Pages: 225 - 234
Abstract
Selenium (Se) deficiency in the experimental models, Coturnix coturnix japonica and Corcyra cephalonica, resulted in impaired mitochondrial substrate oxidations and lowered thiol levels. Studies with respiratory inhibitors confirmed reduced mitochondrial electron transport enzyme activities, especially at cytochrome c oxidase (COX), the terminal segment. Enhanced mitochondrial lipid peroxidation in Se deficiency was more pronounced in the heart tissue of the quail compared to other tissues. Glutathione peroxidase (GSH-Px) activity toward H2O2 and cumene hydroperoxide were generally low in the insect muscle tissue and activity toward H2O2 was maximal in the quail heart mitochondria that was not very sensitive to Se status. Lowered COX activity in Se deficiency was more directly correlated with the increased level of lipid peroxidation than with the GSH-Px activity measured, suggestive of Se mediated protective mechanisms independent of GSH-Px. Electron microscopic observations revealed structural changes such as loss of cristae with proliferative and degenerative changes of the mitochondria in Se deficiency. Involvement of Se in maintaining structure and functional efficiency of mitochondria is evident from the present study.
About the journal
JournalBiological Trace Element Research
PublisherHumana Press Inc.
ISSN01634984
Open AccessNo
Concepts (17)
  •  related image
    Article
  •  related image
    CELL ULTRASTRUCTURE
  •  related image
    Chicken
  •  related image
    Electron transport
  •  related image
    Lipid peroxidation
  •  related image
    MITOCHONDRIAL RESPIRATION
  •  related image
    Mitochondrion
  •  related image
    Newborn
  •  related image
    Nonhuman
  •  related image
    SELENIUM DEFICIENCY
  •  related image
    CORCYRA CEPHALONICA
  •  related image
    COTURNIX COTURNIX
  •  related image
    COTURNIX JAPONICA
  •  related image
    Gallus gallus
  •  related image
    Insecta
  •  related image
    JAPONICA
  •  related image
    PHASIANIDAE