Growing environmental concerns have spurred technological challenges within the chemical process industries to accommodate the concept of waste minimization. Commercial process simulators such as Aspen Plus, HYSYS, Pro II and ChemCAD, which have been extensively employed to solve plant synthesis problems, are also gaining currencies for achieving the desired waste minimization objectives. However, the use of these simulators is not a straightforward task as it requires considerable know-how, skills and expertise of the user for recognizing the process variables, which hold keys to the overall waste feature of the plant. In this paper, we present an integrated framework comprising of G2 expert system and HYSYS simulator to automate the overall waste minimization procedure. The framework has been developed by extending our previous ENVOPExpert system. Our updated ENVOPExpert capitalizes on the CAPE-OPEN capability of HYSYS process simulator through XML data technology. We illustrate the automated approach using an industrial hydrocarbon separation process from literature.