The effect of deformation temperature (77, 298 and 573 K) on the evolution of slip and twinning modes in Zircaloy-4 was studied. Samples of Zircaloy-4 were uniaxially compressed to different strains at a nominal strain rate of 10−3 s−1. The compression direction was chosen so as to activate twinning. Microstructural examination was carried out using electron backscatter diffraction to relate the evolution of microstructure and texture to the micro-mechanics and work-hardening behaviour. In conjunction with experiments a visco-plastic self-consistent crystal plasticity model was used to determine the evolution of deformation modes. Extensive twinning was observed at all the test temperatures. Twinning activity at 298 and 573 K was comparable, but was lower than that at 77 K. A strong basal texture parallel to the compressive direction was found at 298 and 573 K. The VPSC model predicted well the texture evolution at 298 and 573 K. The basal texture developed at 77 K was found to have partially reoriented back to the initial texture due to secondary twinning. Prism slip was the dominant deformation mode with secondary slip becoming more active at higher temperatures. © 2018 Elsevier B.V.