Fretting fatigue failures of bioimplants such as hip joints and bone plates occurs due to relative sliding motion of two bodies under contact pressure. In this experiment, fretting fatigue performance of plasma nitrided pairs is compared with unmodified pairs in Ringer solution which represents simulated body fluid. Calibrated proof ring with pads was used for applying fretting damage. Unmodified pairs have exhibited high friction and severe oxidation due to high metallurgical compatibility of the pairs. Plasma nitrided titanium alloys pairs have shown significant improvement in fretting fatigue lives over unmodified pairs with low friction between contact pairs. The oxidation at contact is similar to unmodified pairs but the lives are longer. Three body abrasive damage is also evident at the contact. The steady formation of oxides at the contact seems to play an important role in altering friction during fretting fatigue.