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Effect of a glucose-triazole-hydrogenated cardanol conjugate on lipid bilayer membrane organization and thermotropic phase transition
Mani Kamalraj,
Published in Elsevier
2015
Volume: 1081
   
Pages: 124 - 127
Abstract
This work focuses on the membrane perturbation, solubilisation and thermotropic phase transition process of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) MLVs induced by a glucose-triazole-hydrogenated cardanol conjugate (GTHCC). GTHCC is a recently introduced non toxic sugar derivative. Differential scanning calorimetry (DSC) and fluorescence molecular probe based techniques have been used to understand the concentration dependent membrane perturbation, solubilisation and thermotropic phase transition process of DPPC MLVs. The phase transition temperature of DPPC MLVs decreases with increase in mol% of GTHCC. At higher concentration above 10 mol%, GTHCC was significantly perturbed the membrane organization. The intrinsic fluorescence of GTHCC is also found to be sensitive towards phase behaviour and changes in membrane organization of DPPC MLVs. © 2014 Elsevier B.V. All rights reserved.
About the journal
JournalData powered by TypesetJournal of Molecular Structure
PublisherData powered by TypesetElsevier
ISSN00222860
Open AccessNo
Concepts (16)
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    Differential scanning calorimetry
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    Fluorescence
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    Glucose
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    Hydrogenation
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    Lipid bilayers
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    Nitrogen compounds
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    Solubility
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    1 ,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
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    CARDANOLS
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    Concentration-dependent
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    Fluorescence anisotropy
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    FLUORESCENCE MOLECULAR
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    LIPID BILAYER MEMBRANES
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    SOLUBILISATION
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    THERMOTROPIC PHASE TRANSITION
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    Membranes