This paper discusses the dynamic response of a typical prestressed concrete railtrack sleeper due to wheel-track interaction dynamics, involving wheel and rail imperfections, under various parametric conditions. The interaction dynamics of the vehicle and track is first carried out in the time domain using MSC/NASTRAN. Using the resulting load time histories on an isolated sleeper, a detailed finite element model of the sleeper is used to analyze its dynamic behaviour. The dynamic amplification factors for deflection, ballast pressure and bending moments have been evaluated at the critical section (rail-seat and centre) for various exciting frequencies under different vehicle-track parametric conditions. The results provide a basis for improved and rational design of the sleeper.