Background and objective: Recent research and tested data suggested that spinal injuries occur more often in a frontal impact. Most of the published information is focused on the lumbar spinal injury with respect to axial compression force by varying the height of drops. Parametric studies on the lumbar spinal injury are very scanty. Therefore, the present investigation aimed to optimize the effects of drop height, torso weight and seat angle on the characterization of lumbar injury criteria Methods: A detailed finite element model of a spine with multi-segmented spinal columns is developed and validated with the experimental or cadaveric tests using CORA evaluation. Hence, Dynamic loading studies or weight drop techniques were used to characterize the effect of drop height, seat angle and torso weight of the upper body on the lumbar spinal injury during a frontal impact. Parametric simulations were carried out using response surface methodology (RSM). Test of significance (p < 0.05) on the parameters was carried out using ANOVA. Desirability Function Approach is used to optimize the parameters for better safety design. Results: The result shows that all the factors considered in the experiment are related to the risk of lumbar spinal injury during the frontal impact. All the factors selected, the drop height, torso weight and the seat angle were the most prominent element in determining the lumbar spinal injury. The injury increased with the increase in the posture angle of the seat. Optimal parameters were determined for the better safety of the occupants as seat angle of 105°, drop height 500 mm and torso weight of 25 kg in vehicle design. During vertical impact, posterior undergoes maximum impact in the portions of vertebra and confirmed with the patient case study fracture of vertical drop incident. Conclusions: This research insight gives an improved understanding of the parametric influence of design alternatives to minimize the risk of lumbar spinal injury in automotive vehicles. The optimal combination of drop height and the seat angle provides futuristic view on autonomous vehicle seat design. © 2020 Elsevier B.V.