In this work detection of pulmonary abnormalities carried out using flow-volume spirometer and Radial Basis Function Neural Network (RBFNN) is presented. The spirometric data were obtained from adult volunteers (N=100) with standard recording protocol. The pressure and resistance parameters were derived using the theoretical approximation of the activation function representing pressure-volume relationship of the lung. The pressure-time and resistance-expiration volume curves were obtained during maximum expiration. The derived values together with spirometric data were used for classification of normal and obstructive abnormality using RBFNN. The results revealed that the proposed method is useful for detecting the pulmonary functions into normal and obstructive conditions. RBFNN was found to be effective in differentiating the pulmonary data and it was confirmed by measuring accuracy, sensitivity, specificity and adjusted accuracy. As spirometry still remains central in the observations of pulmonary function abnormalities these studies seems to be clinically relevant. © 2007 Springer Science+Business Media, LLC.