In the present study, using ICME approach, the development of Co-Cr-Fe-Ni-V based single-phase FCC high entropy alloy (HEA) has been explored. The simulation guided composition was arc melted and verified using microstructure characterization. The as-cast sample was subjected to deformation at a strain rate of 0.1 s−1in the temperature range of 1073–1373 K. The flow stress behavior in this temperature range could be correlated with the evolution of microstructure using EBSD. Based on these results, the deformation behavior of the alloy at elevated temperature is rationalized. The current study realizes the ICME approach to develop novel single-phase FCC HEA. © 2021 Elsevier B.V.