Mesoscale models are highly competent for understanding behaviour of unreinforced masonry structures. Their only limitation is large computational expense. Fully Equivalent Operational Model forms an equivalent mathematical model to represent a particular phenomenon where explicit relationship between inputs and outputs are unknown. This paper explores the ability of a major variant of High Dimensional Model Representation (HDMR) technique, namely Cut-HDMR, to construct the most efficient Fully Equivalent Operational Model for nonlinear finite element analysis of mesoscale model of an unreinforced masonry structure. Conclusions are reached on various aspects such as, suitability of interpolation schemes and order of Cut-HDMR approximation. © 2012 Indian Academy of Sciences.