This paper compares the response of a jacket-supported offshore wind turbine (OWT) under wave loading, when (a) soil-structure interaction (SSI) is ignored and (b) SSI is considered. The jacket is placed in a water depth of 70. m and soil conditions off the west coast of India are used in the study. The rotor of the OWT is considered to be parked, under a survival average wind speed of 50. m/s, significant waver height Hs=16. m and peak spectral period Tp=18. s. The significance of includng SSI in OWT studies is investigated by means of pushover analyses and irregular-wave dynamic analyses. Modal studies are performed to determine the variation in the free-vibration response of the two cases. It is observed that ignoring SSI tends to over-estimate the ultimate strength characteristics of the OWT by 3-60% in various modes or increase the tower top displacement above serviceable limit. For dynamics analysis, the wave elevation is generated using wave superposition method. The JONSWAP wave spectrum is discretized using constant area method which introduces additional uncertainty. The analysis shows that approximately 200 frequencies are necessary using constant area method to capture the tail region appropriately. Also the statistical uncertainty in the generation of wave elevation for dynamic analyses is quantified by means of sample convergence studies. The results show that approximately 20-40 samples are required in order to obtain reasonable statistics. © 2015 Elsevier Ltd.