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Copper perchlorate: Efficient acetylation catalyst under solvent free conditions
Kandasamy Jeyakumar,
Published in
2006
Volume: 255
   
Issue: 1-2
Pages: 275 - 282
Abstract
Acetylation of alcohols, phenols, amines, thiols and aldehydes is performed using acetic anhydride as acylating agent and M(ClO4)2·6H2O as catalyst where M is Mn, Co, Ni, Cu and Zn at room temperature under solvent free conditions. Transition metal perchlorates used here are found to be more efficient than the already reported metal triflates and s, p-block perchlorates. Substrates containing acid sensitive protecting groups are acylated successfully without any cleavage of the protection. Remarkably, less nucleophlic thiols (e.g. 2-mercaptobenzothiazole) are acylated with reasonable yields using transition metal perchlorates as catalyst whereas otherwise active acylation catalyst Mg(ClO4)2 was found to be inefficient. © 2006 Elsevier B.V. All rights reserved.
About the journal
JournalJournal of Molecular Catalysis A: Chemical
ISSN13811169
Open AccessNo
Concepts (10)
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    Acylation
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    Alcohols
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    Aldehydes
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    Copper compounds
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    Solvents
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    ACETIC ANHYDRIDE
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    Heteroatoms
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    METAL TRIFLATES
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    TRANSITION METAL PERCHLORATES
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    Catalyst activity