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Convenient Synthesis of 3-Glycosylated Isocoumarins
Kasireddy Sudarshan,
Published in Wiley-VCH Verlag
Volume: 2017
Issue: 1
Pages: 34 - 38
A new route for the synthesis of 3-substituted and 8-hydroxy-3-substituted isocoumarins was developed by modified Julia olefination for initial C–C bond formation between aldehydes and benzylic sulfones. Palladium-catalyzed Meinwald rearrangement was used as a key step for the obtainment of ketone intermediates, which – upon base-promoted intramolecular cyclization – afforded the desired isocoumarins. The developed method paves the way to hitherto unknown 3-glycosylisocoumarins, in general, and 3-glucosylisocoumarins, in particular, wherein the glucosyl moiety is attached to the pyrone ring of the isocoumarin framework. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
About the journal
JournalData powered by TypesetEuropean Journal of Organic Chemistry
PublisherData powered by TypesetWiley-VCH Verlag
Open AccessNo