Convenient synthesis of 2-β-d-Glucopyranosylpyridines has been achieved by using Bohlmann–Rahtz heteroannulation reaction between a sugar alkynone and ethyl β-aminocrotonate. The synthesized compounds are analogues of Dapagaliflozin, an approved drug for lowering of blood glucose levels through inhibition of sodium-glucose transporters in the kidney. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Indrapal Singh Aidhen

Department Of Chemistry

Mannem Rajeswara Reddy

IIT Madras is a public technical and research university located in Chennai, Tamil Nadu. Founded in 1959, it is recognised as an Institute of National Importance.

IIT Madras has been ranked as the top engineering institute in India for four years in a row by the National Institutional Ranking Framework of the MHRD

It currently offers undergraduate, postgraduate and research degrees across 16 disciplines in Engineering, Sciences, Humanities and Management. About 596 faculty belonging to science and engineering departments and centres of the Institute are engaged in teaching, research and industrial consultancy.

IIT Madras

European Journal of Organic Chemistry

A convenient and scalable synthetic approach has been developed for the synthesis of acyl-C-β-d-glucosides and benzyl-C-β-d-glucosides. The use of Weinreb-amide (WA) functionality was crucial for this accomplishment as the other apparently capable alternatives, had severe limitations for the access to acyl-C-glucosides. The synthesized compounds, acyl and benzyl-C-glucosides promote glucose-uptake activity in the C2C12 (mouse skeletal muscle) cell lines through PPAR-γ mediated GLUT4 expression. The developed synthetic scheme for acyl-and benzyl-C-β-d-glucosides and biostudies evaluating their activity as glucose-uptake promoters are disclosed herein. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Acyl and Benzyl-C-β-D-Glucosides: Synthesis and Biostudies for Glucose-Uptake-Promoting Activity in C2C12 Mytotubes

Inorganic Chemistry

Synthesis of Zintl Triads Comprising Extended Conjugated π-Electronic Systems: [RGe9–CH═CH–CH═CH–Ge9R]4–(R = −CH═CH2, −C(CH3)═CH–CH═N(CH2)2NH2)

Proceedings of the National Academy of Sciences

Functional expression of sodium-glucose transporters in cancer

Structure of human endothelial nitric oxide synthase heme domain IN COMPLEX WITH 6-((((3S, 5R)-5-(((6-AMINO-4-METHYLPYRIDIN-2-YL)METHOXY) METHYL)PYRROLIDIN-3-YL)OXY) METHYL)-4-METHYLPYRIDIN-2-AMINE

Organic Letters

Efficient Synthesis of Empagliflozin, an Inhibitor of SGLT-2, Utilizing an AlCl3-Promoted Silane Reduction of a β-Glycopyranoside

MedChemComm

On the importance of synthetic organic chemistry in drug discovery: reflections on the discovery of antidiabetic agent ertugliflozin

Convenient Access to 2-β-d-Glucopyranosylpyridines by Using Bohlmann–Rahtz Heteroannulation

Journal	Data powered by TypesetEuropean Journal of Organic Chemistry
Publisher	Data powered by TypesetWiley-VCH Verlag
ISSN	1434193X
Open Access	No