The pathogenic role of these 2 autoantibodies remains to be established, but it is known that immunization of mice with a Ro peptide recapitulates many signs and symptoms of SS (4), associated with increased IL-12 expression in the salivary glands (Yin H, et al: unpublished observations). Finally, we completely agree with the conclusion that SS may comprise different pathogenetic entities leading to shared clinical manifestations.